Penicillin VK
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Penicillin VK
Contents |
Pharmacodynamics
Penicillin is a Beta-lactam antibiotic, in the natural penicillins subclass. By binding to the appropriately named penicillin binding proteins (PBPs) it inhibits cell wall synthesis.
Pharmacokinetics
Spectrum Of Activity
Gram Positive
- Streptococcus sp.
- Staphalococcus sp.
- Enterococcus sp.
Spirochetes
- Treponema Pallidum
- Borellia sp.
Drug Interactions
Probenecid will prolong the half-life of penicillin
Penicillin will decrease vitamin K production in the gut, leading to an increase in INR when used in conjunction with warfarin.
Pencillin interacts with estrogen containing contraceptives by decreasing the enterohepatic recycling of estrogen by gut bacteria. This interaction is not well documented.
Adverse Drug Reactions
Superinfection
May lower the seizure threshold
