From Ask Dr Wiki
Penicillin is a Beta-lactam antibiotic, in the natural penicillins subclass. By binding to the appropriately named penicillin binding proteins (PBPs) it inhibits cell wall synthesis.
Spectrum Of Activity
- Streptococcus sp.
- Staphalococcus sp.
- Enterococcus sp.
- Treponema Pallidum
- Borellia sp.
Probenecid will prolong the half-life of penicillin
Penicillin will decrease vitamin K production in the gut, leading to an increase in INR when used in conjunction with warfarin.
Pencillin interacts with estrogen containing contraceptives by decreasing the enterohepatic recycling of estrogen by gut bacteria. This interaction is not well documented.
Adverse Drug Reactions
May lower the seizure threshold