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Thyrotropic insufficiency, also known as thyrotrophic insufficiency or thyrotropic deficiency, is partial insufficiency of the anterior pituitary or the respective component of total hypopituitarism, where deficient thyrotropin secretion leads to understimulation of the thyroid gland with consecutive secondary hypothyroidism.
Depending from severity the following types are differentiated:
- partial thyrotropic insufficiency with residual pituitary function:
- complete thyrotropic insufficiency (TSH and FT4 reduced).
Thyrotropic insufficiency may be caused by the following disorders:
- Pituitary apoplexy
- Pituitary adenoma
- Pickardt-Fahlbusch syndrome
- Hypothalamic damage (with consecutive tertiary hypothyroidism)
- Craniocerebral injury
Treatment relies on substitution with thyroxine. However, the substitution dose is adjusted in dependence from FT4 levels and not (as usual in primary hypothyroidism) from TSH levels.
- ↑ Dietrich JW, Landgrafe, G, Fotiadou, EH. TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis Journal of Thyroid Research, vol. 2012, Article ID 351864, 29 pages, 2012. doi:10.1155/2012/351864. PMID 23365787.
- Rappaport R, Comar D, Rivière R, Cachin O, Royer P. L'insuffisance thyreotrope: exploration fonctionnelle et etude clinique (a propos de 28 observations d'insuffisance hypothalamo-hypophysaire) [Thyrotropic insufficiency: functional exploration and clinical study (apropos of 28 cases of hypothalamo-hypophyseal insufficiency)]. Arch Fr Pediatr. 1967 Apr;24(4):399-413. French. PMID 6077788.